MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT)
H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
CAS: 131334-43-5
Molecular Formula: C72H104N20O16S
MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT) - Names and Identifiers
MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT) - Physico-chemical Properties
| Molecular Formula | C72H104N20O16S |
| Molar Mass | 1537.79 |
| Density | 1.332±0.06 g/cm3(Predicted) |
| Boling Point | 1897.4±65.0 °C(Predicted) |
| Appearance | White to off-white powder. |
| pKa | 3.49±0.10(Predicted) |
| Storage Condition | Room Temprature |
| In vitro study | Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151). |
| In vivo study | PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease. |
MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT) - References
| biological activity | PLP (139-151) is a myelin protein lipoprotein (PLP) 139 to 151 amino acid fragment. For the induction of experimental autoimmune encephalomyelitis (EAE). |
Last Update：2024-04-09 19:05:18
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CAS: 131334-43-5
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Mobile: 18021002903
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